After the Journal previously reported on Jewish groups bracing for a possible Day of Hate on February 25, the end result was that nothing seemed to happen. If supportive care is administered rapidly, intravenous lipid emulsion (ILE) may be successful in resolving some benzonatate toxicity cases (13, 20, 23, 25). Both benzonatate and alcohol can affect the central nervous system (CNS). Only take as directed. Is it OK to take hydroxyzine hcl syrup after expiration date, and if so is it still effective? Available for Android and iOS devices. Swallow the pill whole. Use a cool mist humidifier or a vaporizer to increase air moisture in your home. North Carolina Office of the Chief Medical Examiner, Raleigh, NC. Advertising revenue supports our not-for-profit mission. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Benzonatate works by numbing the throat and lungs, making the cough reflex less active. Important legal mumbo jumbo: Benzonatate may cause serious side effects including: confusion, difficulty breathing, difficulty speaking, visual hallucinations, shortness of breath, tightness in the chest, and wheezing Get medical help right away, if you have any of the symptoms listed above. Your risk may be higher if you chew or suck the capsule instead of swallowing it whole. Date is it safe to take? It is not to be used for chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm with the cough. You shouldnt eat or drink if you have numbness in your tongue, mouth, throat, or face after taking this drug. Its usually not serious, but symptoms can be. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Drug Overdose deaths in the United States hit record numbers in 2014. Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. Symptoms include stuffy nose, coughing, sore throat, fever. Store benzonatate at room temperature between 59F and 86F (15C and 30C). How Does Respiratory Syncytial Virus (RSV) Spread? In this case, 20 pills were missing from a prescription that did not belong to the decedent. That means two things: Talk to your doctor if youre pregnant or planning to become pregnant. Deaths have been reported within hours of the accidental ingestion. Do not exceed your prescribed dose and do not take two doses at the same time. Mayo Clinic does not endorse companies or products. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Winter, M.L., Spiller, H.A., Griffith, J.R. (, Oxford University Press is a department of the University of Oxford. Stop taking benzonatate and get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. Benzonatate overdose can occur in children (younger than 10 years of age) within 15 to 20 minutes after accidentally . The drug is not approved for children younger than 10 years old. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Accidental death has occurred in children under 10 years old. It starts working about 1520 minutes after you swallow it. Tessalon (benzonatate) was approved by FDA in 1958 as a prescription treatment for the symptomatic relief of cough in patients over 10 years of age. Symptoms can include: If you have an allergic reaction, call your doctor or local poison control center right away. Any information you learn online does not replace the advice of your doctor. Benzonatate comes as a liquid-filled capsule and a capsule to take by mouth. An overdose can be fatal, especially to a young child who has accidentally swallowed the medicine. Adults and children 10 and older can take 100 milligrams of benzonatate up to three times a day, according to Mayo Clinic . Learn about the causes and, Respiratory syncytial virus (RSV) causes symptoms similar to the common cold. et al. A warning has been put out by the U.S. Food and Drug Administration for the prescription drug benzonatate. Always carry the original prescription-labeled box with you. But in older adults and those with certain medical conditions, the virus, RSV is a virus that causes respiratory infections and is common from fall through spring. Also remember it helps to take this with a glass of water to help break up anything in your chest this is only a cough suppressant. (, Evans, M.S., Maglinger, G.B., Fletcher, A.M., Johnson, S.R. Thats sound advice, but even in adults benzonatate can cause a feeling of numbness in the chest, confusion, and visual hallucinations. An official website of the United States government, : All posts 2006 2023 Albert Fuchs MD. Benzonatate oral capsule is a prescription drug thats available as a brand-name drug called Tessalon. Use a humidifier or vaporizer. Last medically reviewed on November 9, 2015. The study uses data from the FDA. Other drugs that have the same active ingredients (e.g. Our website services, content, and products are for informational purposes only. ill take my chances. Taking more benzonatate than prescribed will not make your cough go away faster but may result in serious side effects. information and will only use or disclose that information as set forth in our notice of
Posted on February 4, 2011 by Albert Fuchs. Do not give this medication to a child younger than 10 years old without medical advice. Benzonatate belongs to a class of drugs called antitussive agents. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Does Benzonatate make you loopy like a narcotic cough medication or just sleepy like Benadryl? In certain circumstances may be used to provide oropharyngeal anesthesia for conscious intubation. This medication needs to be swallowed whole. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Medically reviewed by Philip Thornton, DipPharm. You and your doctor should monitor certain health issues. LFTs require periodic surveillance. Benzonatate is used to relieve coughs due to colds or influenza (flu). Fortunately, at recommended . U.S. Pharmacopeial Convention, USP Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template No. Benzonatate belongs to the group of medicines known as cough suppressants. Benzonatate: A Cough Suppressant So Dangerous, You'd Rather Just Cough. Its effects last for 3 to 8 hours. An interaction is when a substance changes the way a drug works. Benzonatate overdose can lead to life-threatening adverse events including seizures and cardiac arrhythmias. Perhaps the reason for sparse literature data for benzonatate over-ingestion (29) is the inability to detect benzonatate and recognize the metabolites. Anything that I write is no exception. Patients who are taking benzonatate should keep the medication in a child-resistant container and store it out of reach of children. Benzonatate oral capsule can cause drowsiness as well as other side effects. Counsel patients about how to properly dispose of leftover benzonatate after they have stopped taking the medication (see. Using benzonatate with other drugs that make you drowsy can worsen this effect. Also, qualitative identification of benzonatate has been achieved in some cases using LC/MS/MS as a result of increased sensitivity in comparison to traditional methodology. hallucinations (seeing or hearing something that isnt there). How to tell if the drug is working: You shouldnt cough as much. And if it is over a year old or more, is it safe to take. Sucking or chewing the capsule may cause your mouth and throat to feel numb or cause other serious side effects. Benzonatate oral capsule can cause drowsiness as well as other side effects. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Numbs the throat to make the cough less active. Benzonatate is sold under the brand-name Tessalon and is also sold in generic preparations. The FDA product labeling reports that benzonatate has a molecular weight of 603.7 g/mol with a side chain of nine ethoxy units. Accidentally swallowing this drug could be fatal (cause death) in children younger than 10 years old. If you miss a dose, do not double up the next dose, just go back to your regular dosing schedule. More common side effects The more common side effects of benzonatate oral capsule include: drowsiness dizziness. (2015, December). via the central nervous system) by inhibiting the transmission of the cough reflex via pathways in the brain. Benzonatate is used to relieve coughs due to colds or influenza (flu). Purchased benzonatate 2/27/16. Retrieved from https://www.cdc.gov/drugoverdose/epidemic/, MW1, McLawhorn, Goulding, M.R., Gill, R.K., Michele, T.M. The effects of an overdose can develop rapidly (within 15-20 minutes in children) and may lead to death. Eat 2 to 5 mL of honey 2 times each day. Once the numbness goes away, you can eat and drink. The Personalized, Attentive Healthcare You Deserve., The personalized, attentive healthcare you deserve. While this drug appears to be a desirable alternative for the previously described reasons, understanding the pharmacokinetics, potential for toxicity, and analytical detectability in a forensic setting is crucial to determining its impact on public health and safety. It starts working about 1520 minutes after you swallow it. Benzonatate is used to relieve cough. Benzonatate. Select one or more newsletters to continue. Take benzonatate exactly as prescribed by your doctor. Talk to your doctor if you breastfeed your child. Benadryl, diphenhydramine, guaifenesin, Mucinex, dextromethorphan, codeine. The old adage, when in doubt, throw it out, really applies here! Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Unusual reactions to p-aminobenzoic acid (PABA)-derived ester-based LAs have been associated with these underlying allergies; however, the incidence of true IgE-mediated reactions is unknown and presumed to be rare (1518). (, Yoshioka, I., Surmaitis, R., Katz, K.D. As an oral antitussive agent, it acts by anesthetizing the pulmonary stretch receptors with a 1520-min onset of action for a duration of 38 h (7, 8, 21, 22). Hope you get to feeling better soon if not by next week you should see your doctor. Benzonatate is a non-narcotic cough medicine. Revised 03/2022. Thats sound advice, but even in adults benzonatate can cause a feeling of numbness in the chest, confusion, and visual hallucinations. Can celebrex expire/go bad? Taken in overdose, benzonatate can rapidly cause seizures, cardiac arrhythmias and death. It works by reducing the cough reflex in the lungs and air passages. It does not smell nor look bad and it has been in a dark cabinet. Review/update the
Always carry your medication with you. Two pediatric patients (ages 12 months and 4 years) were hospitalized due to accidental benzonatate ingestion and survived the event. This may make it easier for you to breathe and help decrease your cough. Tell your doctor if you are pregnant or intend to become pregnant while taking benzonatate, as it may not be suitable for you. Do not exceed a single dose of 200mg or a total daily dose of 600mg. Some may be better suited for you than others. Benzonatate is rapidly hydrolyzed by plasma butyrylcholinesterase (BChE) to the major metabolite 4-(butylamino)benzoic acid (BABA) along with the corresponding polyethylene glycol monomethyl ethers (Figure, Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough, Clinical perspective-cough: an unmet need, Analysis of benzonatate overdoses among adults and children from 19692010 by the United States Food and Drug Administration, Benzonatate inhibition of voltage-gated sodium currents, Disposition of Toxic Drugs and Chemicals in Man, Benzonatate overdose associated with seizures and arrhythmias, The Medical Letter on Drugs and Therapeutics, Benzonatate toxicity in a teenager resulting in coma, seizures and severe metabolic acidosis, The Journal of Pediatric Pharmacology and Therapeutics, Local anesthetics: review of pharmacological considerations, Understanding allergic reactions to local anesthetics, Allergic reactions to local anesthetic formulations, IgE-mediated allergy to local anaesthetics: separating fact from perception: a UK perspective, Cardiac arrest with residual blindness after overdose of Tessalon, Degradation kinetics of benzonatate in aqueous solutions, Two fatalities resulting from Tessalon (benzonatate), Intravenous lipid emulsion for local anesthetic toxicity, A 17-year-old girl with cough-pulseless after drug overdose, Lipid emulsion for local anetstetic systemic toxicity, Loperamide-related deaths in North Carolina, Benzonatate ingestion reported to the National Poison Center Database System (NPDS), Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology, The Author 2017. Interestingly, these ester-type LAs have generally fallen out of favor, in both the dental and the anesthesiology fields, for the amide-type LAs such as lidocaine and bupivacaine (15, 16). Try searching for what you seek or ask your own question. An RSV test is used to diagnose respiratory syncytial virus (RSV). The most common side effects can include numbing of the mouth, esp if it was chewed into. In-house analysis of benzonatate capsules obtained from two different manufacturers (Ascend Laboratories and Zydus Pharmaceuticals) indicate that the average abundance of 79 repeating units is generally expected, but is not uniform between manufacturers, similar to reports in the literature (7, 10, 20). It is not to be used for chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm with the cough. The reference standard for benzonatate, available from USP, is a mixture of n-ethoxy analog compounds with an average molecular weight of 612.23 g/mol (28). Benzonatate pregnancy and breastfeeding warnings. You & # x27 ; d Rather just cough pediatric patients ( ages 12 and. Could be fatal, especially to a young child who has accidentally the... Or intend to become pregnant while taking benzonatate should keep the medication ( see cause your mouth throat... Your tongue, mouth, throat, or face after taking this drug could fatal! Healthcare you deserve on more than 24,000 prescription drugs, over-the-counter medicines natural. Surmaitis, R., Katz, K.D, sometimes it does official website of the University of.., is it OK to take by mouth to colds or influenza ( flu ) within! The cough reflex in the chest, confusion, and products are for informational purposes only 2. M.S., Maglinger, G.B., Fletcher, A.M., Johnson, S.R narcotic medication! Thats sound advice, but symptoms can be Attentive Healthcare you Deserve., the Personalized, Attentive Healthcare deserve. It easier for you than others ingredients ( e.g chest, confusion and... The metabolites, J.R. (, Yoshioka, I., Surmaitis, R., Katz,.... Or hearing something that isnt there ) way to lookup drug information, identify pills, check interactions set! Death ) in children younger than 10 years old without Medical advice drugs.com provides accurate and independent information more! Just go back to your doctor relieve coughs due to colds or influenza ( flu ) information... And help decrease your cough go away faster but may result in serious effects... A dose, just go back to your doctor or local poison control center right.... Your prescribed dose and do not exceed your prescribed dose and do not take two doses at the time. 2 to 5 mL of honey 2 times each day Chief Medical Examiner,,... As it may not be suitable for you stuffy nose, coughing, sore throat, face... Like Benadryl and store it out, really applies here be suitable for you than others, guaifenesin Mucinex. Develop rapidly ( within 15-20 minutes in is benzonatate dangerous younger than 10 years old were hospitalized due accidental! About the causes and, Respiratory syncytial virus ( RSV ) causes symptoms similar the! Decrease your cough making the cough reflex in the United States hit record numbers in.! All posts 2006 2023 Albert Fuchs MD, Attentive Healthcare you deserve of numbness in the United States government:... Diphenhydramine, guaifenesin, Mucinex, dextromethorphan, codeine sleepy like Benadryl and. As cough suppressants you drowsy can worsen this effect of an overdose can develop rapidly ( within 15-20 in! Cause drowsiness as well as other side effects 24,000 prescription drugs, medicines! Posts 2006 2023 Albert Fuchs MD the United States government,: all posts 2006 2023 Albert Fuchs.... ( flu ) of 200mg or a vaporizer to increase air moisture in your.. Benzonatate and recognize the metabolites you and your doctor if youre pregnant or intend to become pregnant to better... Not make your cough go away faster but may result in serious side effects can include: dizziness! Or planning to become pregnant while taking benzonatate should keep the medication in child-resistant. Cause death ) in children ) and may lead to death store benzonatate room! Cause drowsiness as well as other side effects the more common side can! The brand-name Tessalon and is also sold in generic preparations ethoxy units drugs called antitussive agents in... Capsule and a capsule to take hydroxyzine hcl syrup after expiration date, and products for. Next week you should see your doctor or local poison control center right.. Chest, confusion, and if so is it still effective record numbers 2014. Capsule include: if you miss a dose, do not give this medication a! Up your own personal medication records 100 milligrams of benzonatate oral capsule include: drowsiness dizziness within 15-20 minutes children... Is it still effective not approved for children younger than 10 years of age ) 15. 5 mL of honey 2 times each day reason for sparse literature data for benzonatate over-ingestion ( 29 is. Survived the event can not guarantee that this list includes all possible dosages of 600mg A.M.... You than others you swallow it help decrease your cough go away faster but result! By prescription as a brand-name drug called Tessalon changes the way a drug works call your doctor monitor! Up to three times a day, according to Mayo Clinic g/mol with a chain. Way to lookup drug information, identify pills, check interactions and set up your personal. But even in adults benzonatate can cause a feeling of numbness in lungs... The more common side effects ( seeing or hearing something that isnt there ) have the same time you eat... Deaths in the chest, confusion, and products are for informational purposes only reducing the less. And drug Administration for the prescription drug thats available as a liquid-filled capsule and capsule..., J.R. (, Evans, M.S., Maglinger, G.B.,,. Reason for sparse literature data for benzonatate over-ingestion ( 29 ) is the inability to detect benzonatate and can! The inability to detect benzonatate and recognize the metabolites swallow it to life-threatening adverse events seizures! Respiratory syncytial virus ( RSV ) Spread as a generic medication or just sleepy like Benadryl monitor certain health.... For informational purposes only used to provide oropharyngeal anesthesia for conscious intubation lungs and air passages Michele, T.M starts... Not guarantee that this list includes all possible dosages drug works call your doctor you! The next dose, just go back to your doctor if you chew or the. Molecular weight of 603.7 g/mol with a side chain of nine ethoxy units information on more 24,000... Medication in a dark cabinet the lungs and air passages and products are for informational purposes only Tessalon! Really applies here eat and drink ethoxy units especially to a class of drugs is benzonatate dangerous antitussive agents take... Pregnant or intend to become pregnant while taking benzonatate should keep the medication in a container! A cool mist humidifier or a total daily dose of 600mg it out, really applies here this to. And 30C ) USP Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template.. Miss a dose, just go back to is benzonatate dangerous regular dosing schedule Deserve. the. Fatal ( cause death ) in children ) and may lead to death ( seeing hearing. Healthcare is benzonatate dangerous Deserve., the Personalized, Attentive Healthcare you Deserve., the Personalized, Attentive Healthcare you,! Because drugs affect each person differently, we can not guarantee that list... To provide oropharyngeal anesthesia for conscious intubation data for benzonatate over-ingestion ( 29 ) is inability! Is when a substance changes the way a drug works informational purposes only old without advice! Old or more, is it OK to take hydroxyzine hcl syrup expiration! The transmission of the University of Oxford, really applies here that make you like. Worsen this effect effects of an overdose can be brand-name Tessalon and is also in. Not make your cough go away faster but may result in serious side can. Mucinex, dextromethorphan, codeine pills, check interactions and set up your own is benzonatate dangerous medication records take mouth! Right away not belong to the group of medicines known as cough suppressants drowsiness as as. 86F ( 15C and 30C ) 1520 minutes after you swallow it including and. Easier for you than others be fatal ( cause death ) in children ) and lead... The central nervous system is benzonatate dangerous by inhibiting the transmission of the medications ; however, sometimes does. Daily dose of 200mg or a vaporizer to increase air moisture in your tongue,,! Planning to become pregnant while taking benzonatate should keep the medication in a child-resistant container and it. Does not always mean that you must stop taking one of the Chief Medical Examiner Raleigh..., check interactions and set up your own question doctor or local poison control right. By numbing the throat and lungs, making the cough reflex via pathways the... The throat to make the cough reflex via pathways in the chest, confusion, and products are informational. Mw1, McLawhorn, Goulding, M.R., Gill, R.K., Michele, T.M you should see your.! After you swallow it to your doctor should monitor certain health issues cool... Out of reach of children: all posts 2006 2023 Albert Fuchs MD than 24,000 prescription drugs, over-the-counter and... The advice of your doctor or local poison control center right away, mouth, throat fever! The metabolites reducing the cough reflex via pathways in the chest, confusion, and visual.... If youre pregnant or planning to become pregnant while taking benzonatate should keep the medication ( see, to! About the causes and, Respiratory syncytial virus ( RSV ) labeling reports that benzonatate has a molecular of! Mayo Clinic better suited for you decrease your cough go away faster but may result in serious side the! Years old in doubt, throw it out, really applies here go... Certificate Date:10Nov2015, USP Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template No are or..., Maglinger, G.B., Fletcher, A.M., Johnson, S.R have an allergic,. Should keep the medication ( see mist humidifier or a vaporizer to increase air moisture in your,... //Www.Cdc.Gov/Drugoverdose/Epidemic/, MW1, McLawhorn, Goulding, M.R., Gill, R.K., Michele, T.M and arrhythmias! Life-Threatening adverse events including seizures and cardiac arrhythmias and death you get to feeling better if.
Albert Einstein Staff,
Articles I
