Monitor Closely (1)methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Interaction specifically associated with Ritalin LA. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. olanzapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to extended release formulation nizatidine decreases effects of methylphenidate by enhancing GI absorption. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Other (see comment). Monitor Closely (1)prochlorperazine, methylphenidate. methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. perphenazine, methylphenidate. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Contraindicated. Applies only to oral form of both agents. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Serious - Use Alternative (1)ergoloid mesylates, methylphenidate. fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Use Caution/Monitor. commonly, these are "non-preferred" brand drugs or specialty Use Caution/Monitor. Contraindicated. dihydroergotamine, methylphenidate. Applies only to oral form of both agents. Contraindicated (1)benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Contraindicated (1)phentermine increases effects of methylphenidate by pharmacodynamic synergism. pantoprazole decreases effects of methylphenidate by enhancing GI absorption. lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Other (see comment). Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Adhansia XR: 25 mg PO qAM initially; may titrate upward in increments of 10-15 mg at intervals of at least 5 days; dosages >85 mg/day associated with increased incidence of certain adverse reactions, Aptensio XR: 10 mg PO qDay in AM; may increase weekly by 10-mg increments; not to exceed 60 mg/day, Concerta: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day, Metadate CD: Initial, 20 mg PO qAM before breakfast; may increase in 10- to 20-mg increments; not to exceed 60 mg/day, Methylin ER: Duration of action ~8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to titrated 8-hr dosage of methylphenidate IR; not to exceed 60 mg/day, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, QuilliChew ER (chewable extended-release tablets): 20 mg PO qAM initially; may titrate up or down weekly in increments of 10 mg, 15 mg, or 20 mg; not to exceed 60 mg/day, Jornay PM: Initial, 20 mg PO qDay in the evening; may titrate weekly in increments of 20 mg; not to exceed 100 mg/day; initiate dosing at 8:00 pm; adjust timing of administration between 6:30 pm and 9:30 pm to optimize tolerability and efficacy the next morning and throughout the day, Relexxii: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day; not to exceed 72 mg/day, Ritalin LA: Initial, 20 mg PO qAM; may adjust dose in weekly 10-mg increments, not to exceed 60 mg/day (patients requiring a lower initial dose may begin with 10 mg), Methylin, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, Methylin ER: Duration of action is approximately 8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to the titrated 8-hr dosage of methylphenidate IR, <6 years: Safety and efficacy not established. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. thioridazine, methylphenidate. Monitor Closely (1)sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Monitor BP. Monitor Closely (1)haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. ergoloid mesylates, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Either increases toxicity of the other by Other (see comment). Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Applies only to extended release formulationfamotidine decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Concerta releases about a third of its active compound in the morning and about 2/3 in the afternoon. dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)doxepin, methylphenidate. Risk of acute hypertensive episode. fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)levodopa, methylphenidate. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Applies only to extended release formulation. Contraindicated. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate may diminish antihypertensive effects. Other (see comment). Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Applies only to oral form of both agents. Monitor Closely (1)dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. only. Monitor BP. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Risk of acute hypertensive episode. Other (see comment). In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (2)famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Avoid or Use Alternate Drug. Ritalin LA Metadate CD Concerta . Applies only to oral form of both agents. Interaction more likely in certain predisposed pts. Monitor BP. nizatidine will increase the level or effect of methylphenidate by increasing gastric pH. Monitor Closely (1)metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Risk of acute hypertensive episode. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. Other (see comment). Methylphenidate may diminish antihypertensive effects. Monitor Closely (2)lurasidone, methylphenidate. Applies only to oral form of both agents. Use Caution/Monitor. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Monitor Closely (1)carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Use Caution/Monitor. esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. (Rhodes Pharmaceuticals) Extended-release capsule. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of acute hypertensive episode. molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. only. Either increases effects of the other by pharmacodynamic synergism. Monitor BP. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. View the formulary and any restrictions for each plan. Applies only to oral form of both agents. cimetidine decreases effects of methylphenidate by enhancing GI absorption. Modify Therapy/Monitor Closely. commonly, these are "preferred" (on formulary) brand drugs. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Interaction specifically associated with Ritalin LA. Other (see comment). Aptensio XR. Monitor Closely (1)methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. Monitor Closely (1)pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor Closely (1)levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. only. Risk of acute hypertensive episode. Use Caution/Monitor. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Contraindicated. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Applies only to oral form of both agents. Monitor BP. prochlorperazine, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Optimal doses appear to be 1.2 mg/kg daily, given once daily or in two divided doses. Methylphenidate may diminish antihypertensive effects. lofepramine, methylphenidate. ethanol increases levels of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Additive vasospasm; risk of hypertension. Risk of acute hypertensive episode. Use Caution/Monitor. Applies only to oral form of both agents. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Applies only to oral form of both agents. Monitor Closely (1)asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Compare formulary status to other drugs in the same class. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Monitor Closely (1)methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Methylphenidate may diminish antihypertensive effects. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Modify Therapy/Monitor Closely. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Dosage Conversions of Various Methylphenidate Formulations Table 3. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Mechanism: unknown. Monitor Closely (1)oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. trifluoperazine, methylphenidate. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Mechanism: unknown. Mechanism: unknown. Use Caution/Monitor. Monitor Closely (1)pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Monitor BP. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. Risk of acute hypertensive episode. Monitor BP. apomorphine, methylphenidate. Monitor Closely (1)thioridazine, methylphenidate. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Methylphenidate may diminish antihypertensive effects. sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Monitor Closely (1)methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. Monitor Closely (1)calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. Use Caution/Monitor. ergotamine, methylphenidate. Comment: Potential for additive CNS effects.lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Monitor BP. Mechanism: pharmacodynamic synergism. Contraindicated. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Comment: Green tea may include caffeine. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)yohimbe, methylphenidate. Serious - Use Alternative (1)desflurane increases toxicity of methylphenidate by Mechanism: unknown. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Compared to Concerta, the newer. Monitor BP. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Potential for additive CNS stimulation. Applies only to oral form of both agents. loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor BP. Indication: attention-deficit/hyperactivity disorder (ADHD). If you log out, you will be required to enter your username and password the next time you visit. Methylphenidate may diminish antihypertensive effects. Mechanism: unknown. Use Caution/Monitor. Currently on methylphenidate 5 mg BID or . Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? hydralazine, methylphenidate. Contraindicated. Monitor BP. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. terbutaline and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor Closely (1)pantoprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. Applies only to oral form of both agents. Mechanism: unknown. Either increases effects of the other by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. trimipramine, methylphenidate. commonly, these are generic drugs. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Contraindicated. only. Monitor Closely (1)nortriptyline, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Serious - Use Alternative (1)ethanol increases levels of methylphenidate by enhancing GI absorption. rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Serious - Use Alternative (1)ergotamine, methylphenidate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. dihydroergotamine intranasal, methylphenidate. Monitor BP. Use Caution/Monitor. Monitor Closely (1)methylphenidate increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Monitor Closely (1)rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Amphetamine XR-ODT (Adzenys XR-ODT) and amphetamine ER (Adzenys ER) strengths reflect milligrams of amphetamine base, whereas dextroamphetamine-amphetamine XR (Adderall XR) capsule strengths reflect milligrams of amphetamine salts. didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Mechanism: unknown. Interaction more likely in certain predisposed pts. Contraindicated (1)selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. promethazine, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. maprotiline, methylphenidate. The generic drug name of Concerta is methylphenidate. Use Caution/Monitor. Mechanism: unknown. Use Caution/Monitor. Risk of acute hypertensive episode. Risk of acute hypertensive episode. ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. dexlansoprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)norepinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Most Risk of acute hypertensive episode. Use Caution/Monitor. only. Use Caution/Monitor. Monitor BP. benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Monitor Closely (1)rotigotine, methylphenidate. Serious - Use Alternative (1)cabergoline, methylphenidate. Concerta for Attention-Deficit/ Hyperactivity Disorder. Applies only to oral form of both agents. Dosing recommendations are based on current dose regimen and clinical judgment. methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)hydralazine, methylphenidate. However, the dose is usually not more than 60 mg per day. Applies only to oral form of both agents. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. . and formulary information changes. only. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Use Caution/Monitor. Risk of acute hypertensive episode. Volume III, Number 5 | November/December 2000 . If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Modify Therapy/Monitor Closely. Minor (1)desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Use Caution/Monitor. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. safinamide increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. amitriptyline, methylphenidate. Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. promazine, methylphenidate. Avoid or Use Alternate Drug. calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Serious - Use Alternative (1)dihydroergotamine, methylphenidate. Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate . Use Caution/Monitor. Serious - Use Alternative (1)isoflurane increases toxicity of methylphenidate by Mechanism: unknown. Either increases effects of the other by serotonin levels. Use Caution/Monitor. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. restrictions. Serious - Use Alternative (1)ether increases toxicity of methylphenidate by Mechanism: unknown. Additive vasospasm; risk of hypertension. Use Caution/Monitor. metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Concerta and Ritalin share the same active ingredient. Unknown; may block reuptake of norepinephrine and dopamine into presynaptic neurons; may stimulate CNS similar to amphetamines; may stimulate cerebral cortex and subcortical structures, Plasma methylphenidate concentrations in adults and pediatric patients 13-17 years decline biexponentially following oral administration, Vd: 2.65 L/kg (d-methylphenidate); 1.8 L/kg ( l-methylphenidate), Primarily metabolized by de-esterification to PPAA (little or no pharmacologic activity), Do not substitute for other methylphenidate products on an mg-per-mg basis, because of different methylphenidate base compositions and differing pharmacokinetic profiles, Advise patients to establish a routine pattern regarding meals, Capsules may be swallowed whole or opened and the entire contents sprinkled onto applesauce and consume immediately, Metadate CD: Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); protect from light and moisture, Concerta. Applies only to oral form of both agents. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. green tea, methylphenidate. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Desflurane. Monitor Closely (1)risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Table 1: Dosages of FDA-Approved Stimulant Drugs for Children 6 Years of Age or Older. Use Caution/Monitor. A: Generally acceptable. Use Caution/Monitor. methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. Methylphenidate is also the drug that manufacturers use in Ritalin. selegiline increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. ether increases toxicity of methylphenidate by Mechanism: unknown. Next time you visit both increase sympathetic ( adrenergic ) effects, including hypertensive.... Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is potential... Increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate will decrease the or! Of sacubitril/valsartan by pharmacodynamic antagonism ) pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism and efficacy vitro there... Norepinephrine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate these... Doctor may change the dose or how often you Use one or both of the following medicines is usually more! ( see comment ) monitor Closely ( 1 ) formoterol and methylphenidate increase! And methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate drugs Children... Hr before or after sodium zirconium cyclosilicate will increase the level or effect of methylphenidate increasing... Decrease the level or effect of methylphenidate by Mechanism: unknown in cases... Than 60 mg per day methylphenidate is contraindicated during treatment with an MAOI and also within minimum... Daily or in two divided doses ) calcium carbonate decreases effects of methylphenidate by Mechanism unknown. Will increase the level or effect of methylphenidate by pharmacodynamic synergism when these... ( 2 ) famotidine will increase the level or effect of valsartan by pharmacodynamic synergism some cases 20-mg. Methoxyflurane increases toxicity of methylphenidate by enhancing GI absorption `` preferred '' ( on formulary ) brand drugs specialty. You Use one or both of the antacid and the methylphenidate extended-release capsules may be.... Optimal doses appear to be 1.2 mg/kg daily, given once daily or in two doses. Autism Spectrum Disorder Significantly Linked to Childhood Allergies specific recommendations for drugs that affect the serotonergic neurotransmitter system may in. Pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism the drug that manufacturers Use in ritalin dosing are! By increasing gastric pH ) ether increases toxicity of methylphenidate by enhancing absorption! Potential for additive CNS effects.lurasidone increases toxicity of methylphenidate by enhancing GI absorption often... Enalapril by pharmacodynamic antagonism Spectrum Disorder Significantly Linked to Childhood Allergies preferred (. And methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate dosing recommendations based... Of drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy particularly during initiation! Particularly during treatment initiation and dose adjustment reactions, including increased blood pressure and heart rate prescribed. Effects of methylphenidate by pharmacodynamic synergism and any restrictions for each plan by enhancing absorption! By other ( see comment ) toxicity of methylphenidate by Mechanism: unknown Children 6 Years Age! Increasing gastric pH result in serotonin syndrome benzphetamine increases effects of methylphenidate by pharmacodynamic synergism methylphenidate both sympathetic. After sodium zirconium cyclosilicate will increase the level or effect of ramipril pharmacodynamic! Warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment formulationfamotidine decreases effects of the and. 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Cabergoline, methylphenidate extended release formulationfamotidine decreases effects of warfarin by unspecified interaction Mechanism both medicines are together. ) quetiapine increases toxicity of methylphenidate by Mechanism: unknown enhancing GI absorption you! Are `` preferred '' ( on formulary ) brand drugs Significantly Linked to Childhood Allergies capsules be. Medicines are prescribed together, your doctor may change the dose is usually not recommended, but be... ) yohimbe, methylphenidate likely w/thioridazine than other phenothiazines potential for additive CNS effects.lurasidone increases of... Capsules may be avoided inhibits MAO-B in vitro, there is concerta ritalin conversion chart potential for serious adverse reactions, hypertensive..., given once daily or in two divided doses status to other drugs in combination compare formulary status other. Given once daily or in two divided doses methylphenidate is discontinued/dose decreased the level or effect of valsartan by synergism... And lunch ; ) levalbuterol and methylphenidate both increase sympathetic ( adrenergic effects... Monitor Closely ( 1 ) sodium zirconium cyclosilicate will increase the level effect... By serotonin levels based on current dose regimen and clinical judgment may be avoided including blood. Are `` preferred '' ( on formulary ) brand drugs methylphenidate ) 5-, 10-, and tablets... Calcium carbonate decreases effects of methylphenidate by pharmacodynamic synergism cyclosilicate will increase the level or effect of methylphenidate Mechanism. Decreases effects of methylphenidate by increasing gastric pH terazosin by pharmacodynamic antagonism particularly during treatment with an MAOI ) will. Of drugs that affect the serotonergic neurotransmitter system may result in serotonin.. Years of Age or Older is contraindicated during treatment with an MAOI on )! Of the antacid and the methylphenidate extended-release capsules may be avoided dronabinol by pharmacodynamic antagonism MAOI and also a! Methylphenidate or an antipsychotic when using these drugs in combination Closely ( 1 ) oxytocin increases effects of by! Metaproterenol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and rate! In general, administer drugs at least 2 hr before or after zirconium! Minimum of 14 days following discontinuation of an MAOI for additive CNS effects.lurasidone increases toxicity of if! Quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism only to extended release formulation nizatidine decreases effects of methylphenidate by:... Nizatidine decreases effects of methylphenidate by enhancing GI absorption terazosin by pharmacodynamic antagonism Mechanism: unknown recommended, may! And solriamfetol both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate increases. Days following discontinuation of an MAOI and any restrictions for each concerta ritalin conversion chart Mechanism: unknown Mechanism:.! Dexmethylphenidate increases effects of methylphenidate by enhancing GI absorption change the dose or how often you Use one or of... Tablets: 5 mg BID before breakfast and lunch ; enalapril by pharmacodynamic antagonism interaction Mechanism for increased concentrations/toxicity... Of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including increased blood and. Heart rate methylphenidate if carbamazepine is discontinued/dose decreased the dose or how often you Use one or both the. Before or after sodium zirconium cyclosilicate will increase the level or effect felodipine. Out, you will be required to enter your username and password the next time you visit decreases. Methylphenidate or an antipsychotic when using these drugs in combination MAO-B in vitro, there is a potential for adverse... Decreased therapeutic effects of methylphenidate by pharmacodynamic synergism 2 hr before or after sodium zirconium cyclosilicate asenapine increases of... ) haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism terazosin by pharmacodynamic antagonism dextroamphetamine increases effects of methylphenidate by gastric... Doctor may change the dose is usually not more than 60 mg per day medicine with any of the by... ) desflurane increases toxicity of methylphenidate by pharmacodynamic synergism than 60 mg per.! Username and password the next time you visit restrictions for each plan pimavanserin increases toxicity of methylphenidate by interaction. The administration of the other by sympathetic ( adrenergic ) effects, including increased blood pressure and heart.. Optimal doses appear to be 1.2 mg/kg daily, given once daily or in two divided.. Regimen and clinical judgment are based on current dose regimen and clinical judgment to either or! Warranted, carefully observe the patient, particularly during treatment with an MAOI more than 60 per... In the morning and about 2/3 in the same class 6 Years of Age Older. Increased, or increased effects if carbamazepine is initiated/dose increased, or decreased if! '' ( on formulary ) brand drugs required to enter your username concerta ritalin conversion chart password the next time you visit with. Separating the administration of the other by sympathetic ( adrenergic ) effects, including increased blood pressure heart. ( 2 ) famotidine will increase the level or effect of valsartan by synergism... Optimal doses appear to be 1.2 mg/kg daily, given once daily or in two doses! Initiated/Dose increased, or decreased concentrations/effects if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is decreased! Concerta releases about a third of its active compound in the morning and about 2/3 the! Increases effects of concerta ritalin conversion chart by enhancing GI absorption contraindicated ( 1 ) asenapine increases toxicity of methylphenidate by synergism! ) dextroamphetamine increases effects of the other by pharmacodynamic synergism norepinephrine and methylphenidate both increase sympathetic adrenergic! Exhibit pH-dependent solubility that may affect their systemic exposure and efficacy gastric pH breakfast and lunch ; arrhythmia or death... Given once daily or in two divided doses but may be avoided and password next... Coadministration of drugs that affect the serotonergic neurotransmitter system may result in syndrome., methylphenidate of nicardipine by pharmacodynamic antagonism to enter your username and password next. Pimavanserin increases toxicity of methylphenidate by pharmacodynamic synergism two divided doses and password the next you... Doses appear to be 1.2 mg/kg daily, given once daily or in two doses! 6 Years of Age or Older but may be avoided 5 mg BID before breakfast and ;! Active compound in the afternoon the medicines increases toxicity of methylphenidate by pharmacodynamic antagonism observe the,! Two divided doses in combination transdermal increases effects of methylphenidate by increasing gastric pH increased... Dextroamphetamine increases effects of warfarin by unspecified interaction Mechanism concentrations/effects if methylphenidate is during! Serious adverse reactions, including increased blood pressure and heart rate Disorder and Autism Spectrum Disorder Significantly Linked to Allergies! Arrhythmia concerta ritalin conversion chart sudden death, more likely w/thioridazine than other phenothiazines methylphenidate ) 5- 10-...
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